Plucked human hair as a tissue in which to assess pharmacodynamic end points during drug development studies

We have demonstrated the feasibility of detecting and quantifying six cell-cycle-related nuclear markers (Ki67, pRb, p27, phospho-p27 (phosphorylated p27), phospho-pRb (phosphorylated pRb), phospho-HH3 (phosphorylated histone H3)) in plucked human scalp and eyebrow hair. Estimates of the proportion of plucked hairs that are lost or damaged during processing plus the intra- and intersubject variability of each nuclear marker with these techniques are provided to inform sizing decisions for intervention studies with drugs potentially impacting on these markers in the future

Measurement of e+e−→γχcJe^+e^- \to \gamma\chi_{cJ} via initial state radiation at Belle

The process $e^+e^- \to \gamma\chi_{cJ}$ ($J$=1, 2) is studied via initial state radiation using 980 fb$^{-1}$ of data at and around the $\Upsilon(nS)$ ($n$=1, 2, 3, 4, 5) resonances collected with the Belle detector at the KEKB asymmetric-energy $e^+e^-$ collider. No significant signal is observed except from $\psi(2S)$ decays. Upper limits on the cross sections between $\sqrt{s}=3.80$ and $5.56~{\rm GeV}$ are determined at the 90% credibility level, which range from few pb to a few tens of pb. We also set upper limits on the decay rate of the vector charmonium [$\psi(4040$), $\psi(4160)$, and $\psi(4415)$] and charmoniumlike [$Y(4260)$, $Y(4360)$, and $Y(4660)$] states to $\gamma\chi_{cJ}$.Comment: Accepted by PR

Evidence for B- -> Ds+ K- l- nubar and search for B- -> Ds*+ K- l- nubar

We report measurements of the decays B- -> Ds(*)+ K- l- nubar in a data sample containing 657x10^6 BBbar pairs collected with the Belle detector at the KEKB asymmetric-energy e+e- collider. We observe a signal with a significance of 6 sigma for the combined Ds and Ds* modes and find the first evidence of the B- -> Ds+ K- l- nubar decay with a significance of 3.4 sigma. We measure the following branching fractions: BF(B- -> Ds+ K- l nubar) = (0.30 +/- 0.09(stat) +0.11 -0.08(syst)) x 10^-3 and BF(B- -> Ds*+ K- l- nubar) = (0.59 +/- 0.12(stat) +/- 0.15(syst)) x 10^-3 and set an upper limit BF(B- -> Ds*+ K- l- nubar) < 0.56 x 10^-3 at the 90% confidence level. We also present the first measurement of the Ds+K- invariant mass distribution in these decays, which is dominated by a prominent peak around 2.6 GeV/c^2.Comment: Submitted to Phys. Rev.

Search for a massive invisible particle X0X^0 in B+→e+X0B^{+}\to e^{+}X^{0} and B+→μ+X0B^{+}\to \mu^{+}X^{0} decays

We present a search for a non-Standard-Model invisible particle $X^0$ in the mass range $0.1\textrm{-}1.8 \,{\rm GeV}/{c^2}$ in $B^{+}\to e^{+} X^{0}$ and $B^{+}\to \mu^{+} X^{0}$ decays. The results are obtained from a $711~{\rm fb}^{-1}$ data sample that corresponds to $772 \times 10^{6} B\bar{B}$ pairs, collected at the $\Upsilon(4S)$ resonance with the Belle detector at the KEKB $e^+ e^-$ collider. One $B$ meson is fully reconstructed in a hadronic mode to determine the momentum of the lepton of the signal decay in the rest frame of the recoiling partner $B$ meson. We find no evidence of a signal and set upper limits on the order of $10^{-6}$.Comment: 8 pages, 4 figures, 3 table

Search for B0B^{0} decays to invisible final states at Belle

We report a search for $B^{0}$ decays into invisible final states using a data sample of $657 \times 10^{6}$ $B\bar{B}$ pairs collected at the $\Upsilon(4S)$ resonance with the Belle detector at the KEKB $e^{+}e^{-}$ collider. The signal is identified by fully reconstructing a hadronic decay of the accompanying $B$ meson and requiring no other particles in the event. No significant signal is observed, and we obtain an upper limit of $1.3 \times 10^{-4}$ at the 90% confidence level for the branching fraction of invisible $B^{0}$ decay.Comment: 6 pages, 5 figures (9 figure files

Search for B+ -> l+ nu gamma decays with hadronic tagging using the full Belle data sample

We search for the decay B+ -> l+ nu gamma with l+ = e+ or mu+ using the full Belle data set of 772 x 10^6 BBbar pairs, collected at the Y(4S) resonance with the Belle detector at the KEKB asymmetric-energy e+e- collider. We reconstruct one B meson in a hadronic decay mode and search for the B+ -> l+ nu gamma decay in the remainder of the event. We observe no significant signal within the phase space of E_gamma^sig > 1 GeV and obtain upper limits of BR(B+ -> e+ nu gamma) mu+ nu gamma) l+ nu gamma) < 3.5 x 10^-6 at 90 % credibility level.Comment: Submitted to Phys. Rev.